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Hydroxyurea induces de novo copy number variants in human cells

Copy number variants (CNVs) are widely distributed throughout the human genome, where they contribute to genetic variation and phenotypic diversity. Spontaneous CNVs are also a major cause of genetic and developmental disorders and arise frequently in cancer cells. As with all mutation classes, gene...

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Hlavní autoři: Arlt, Martin F., Ozdemir, Alev Cagla, Birkeland, Shanda R., Wilson, Thomas E., Glover, Thomas W.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198378/
https://ncbi.nlm.nih.gov/pubmed/21987784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109272108
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