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Hydroxyurea induces de novo copy number variants in human cells

Copy number variants (CNVs) are widely distributed throughout the human genome, where they contribute to genetic variation and phenotypic diversity. Spontaneous CNVs are also a major cause of genetic and developmental disorders and arise frequently in cancer cells. As with all mutation classes, gene...

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Main Authors: Arlt, Martin F., Ozdemir, Alev Cagla, Birkeland, Shanda R., Wilson, Thomas E., Glover, Thomas W.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198378/
https://ncbi.nlm.nih.gov/pubmed/21987784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109272108
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