Replication Stress Induces Genome-wide Copy Number Changes in Human Cells that Resemble Polymorphic and Pathogenic Variants

Copy number variants (CNVs) are an important component of genomic variation in humans and other mammals. Similar de novo deletions and duplications, or copy number changes (CNCs), are now known to be a major cause of genetic and developmental disorders and to arise somatically in many cancers. A maj...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Arlt, Martin F., Mulle, Jennifer G., Schaibley, Valerie M., Ragland, Ryan L., Durkin, Sandra G., Warren, Stephen T., Glover, Thomas W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Human Genetics 2009
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667984/
https://ncbi.nlm.nih.gov/pubmed/19232554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2009.01.024
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