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Replication stress induces tumor-like microdeletions in FHIT/FRA3B
Common fragile sites (CFSs) are loci that preferentially exhibit metaphase chromosome gaps and breaks after partial inhibition of DNA synthesis. The fragile site FRA3B, which lies within the FHIT tumor-suppressor gene, is a site of frequent heterozygous and homozygous deletions in many cancer cells...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2224195/ https://ncbi.nlm.nih.gov/pubmed/18162546 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708097105 |
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