FUT2 Nonsecretor Status Links Type 1 Diabetes Susceptibility and Resistance to Infection

OBJECTIVE: FUT2 encodes the α(1,2) fucosyltransferase that determines blood group secretor status. Homozygotes (A/A) for the common nonsense mutation rs601338A>G (W143X) are nonsecretors and are unable to express histo-blood group antigens in secretions and on mucosal surfaces. This mutation has...

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Hauptverfasser: Smyth, Deborah J., Cooper, Jason D., Howson, Joanna M.M., Clarke, Pamela, Downes, Kate, Mistry, Trupti, Stevens, Helen, Walker, Neil M., Todd, John A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2011
Schlagworte:
Genetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198057/
https://ncbi.nlm.nih.gov/pubmed/22025780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0638
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