The oncoprotein p28(GANK) establishes a positive feedback loop in β-catenin signaling

p28(GANK) (also known as PSMD10 or gankyrin) is a novel oncoprotein that is highly expressed in hepatocellular carcinoma (HCC). Through its interaction with various proteins, p28(GANK) mediates the degradation of the tumor suppressor proteins Rb and p53. Although p53 was reported to downregulate β-c...

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Autors principals: Dong, Li-wei, Yang, Guang-zhen, Pan, Yu-fei, Chen, Yao, Tan, Ye-xiong, Dai, Rong-yang, Ren, Yi-bin, Fu, Jing, Wang, Hong-yang
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3193485/
https://ncbi.nlm.nih.gov/pubmed/21691299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2011.103
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