The Oncoprotein HBXIP Modulates the Feedback Loop of MDM2/p53 to Enhance the Growth of Breast Cancer

MDM2 and p53 form a negative feedback loop, in which p53 as a transcription factor positively regulates MDM2 and MDM2 negatively regulates tumor suppressor p53 through promoting its degradation. However, the mechanism of the feedback loop is poorly understood in cancers. We had reported previously t...

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Vydáno v:J Biol Chem
Hlavní autoři: Li, Hang, Liu, Qian, Wang, Zhen, Fang, Runping, Shen, Yu, Cai, Xiaoli, Gao, Yuen, Li, Yinghui, Zhang, Xiaodong, Ye, Lihong
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4566238/
https://ncbi.nlm.nih.gov/pubmed/26229107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.658468
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