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Stochastic Modeling and Simulation of the p53-MDM2/MDMX Loop

The p53 gene is crucial for effective tumor suppression in humans as supported by its universal inactivation in cancer cells either through mutations affecting the p53 locus directly or through aberration of its normal regulation. The p53 tumor repressor is regulated through a negative feedback loop...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Cai, Xiaodong, Yuan, Zhi-Min
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Mary Ann Liebert, Inc. 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148126/
https://ncbi.nlm.nih.gov/pubmed/19580521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/cmb.2008.0231
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