The oncoprotein p28(GANK) establishes a positive feedback loop in β-catenin signaling

p28(GANK) (also known as PSMD10 or gankyrin) is a novel oncoprotein that is highly expressed in hepatocellular carcinoma (HCC). Through its interaction with various proteins, p28(GANK) mediates the degradation of the tumor suppressor proteins Rb and p53. Although p53 was reported to downregulate β-c...

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Detalhes bibliográficos
Main Authors: Dong, Li-wei, Yang, Guang-zhen, Pan, Yu-fei, Chen, Yao, Tan, Ye-xiong, Dai, Rong-yang, Ren, Yi-bin, Fu, Jing, Wang, Hong-yang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3193485/
https://ncbi.nlm.nih.gov/pubmed/21691299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2011.103
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