The oncoprotein p28(GANK) establishes a positive feedback loop in β-catenin signaling

p28(GANK) (also known as PSMD10 or gankyrin) is a novel oncoprotein that is highly expressed in hepatocellular carcinoma (HCC). Through its interaction with various proteins, p28(GANK) mediates the degradation of the tumor suppressor proteins Rb and p53. Although p53 was reported to downregulate β-c...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Dong, Li-wei, Yang, Guang-zhen, Pan, Yu-fei, Chen, Yao, Tan, Ye-xiong, Dai, Rong-yang, Ren, Yi-bin, Fu, Jing, Wang, Hong-yang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2011
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3193485/
https://ncbi.nlm.nih.gov/pubmed/21691299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2011.103
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