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Suppression of eNOS-derived superoxide by caveolin-1: a biopterin-dependent mechanism
In the vasculature, nitric oxide (NO) is generated by endothelial NO synthase (eNOS) in a calcium/calmodulin-dependent reaction. In the absence of the requisite eNOS cofactor tetrahydrobiopterin (BH(4)), NADPH oxidation is uncoupled from NO generation, leading to the production of superoxide. Althou...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Physiological Society
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3191102/ https://ncbi.nlm.nih.gov/pubmed/21724868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00936.2010 |
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