Suppression of eNOS-derived superoxide by caveolin-1: a biopterin-dependent mechanism

In the vasculature, nitric oxide (NO) is generated by endothelial NO synthase (eNOS) in a calcium/calmodulin-dependent reaction. In the absence of the requisite eNOS cofactor tetrahydrobiopterin (BH(4)), NADPH oxidation is uncoupled from NO generation, leading to the production of superoxide. Althou...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Karuppiah, Kanchana, Druhan, Lawrence J., Chen, Chun-an, Smith, Travis, Zweier, Jay L., Sessa, William C., Cardounel, Arturo J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Physiological Society 2011
Gaiak:
Signaling and Stress Response
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191102/
https://ncbi.nlm.nih.gov/pubmed/21724868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00936.2010
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