Suppression of eNOS-derived superoxide by caveolin-1: a biopterin-dependent mechanism

In the vasculature, nitric oxide (NO) is generated by endothelial NO synthase (eNOS) in a calcium/calmodulin-dependent reaction. In the absence of the requisite eNOS cofactor tetrahydrobiopterin (BH(4)), NADPH oxidation is uncoupled from NO generation, leading to the production of superoxide. Althou...

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Detalhes bibliográficos
Main Authors: Karuppiah, Kanchana, Druhan, Lawrence J., Chen, Chun-an, Smith, Travis, Zweier, Jay L., Sessa, William C., Cardounel, Arturo J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Signaling and Stress Response
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191102/
https://ncbi.nlm.nih.gov/pubmed/21724868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00936.2010
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