Superoxide Induces Endothelial Nitric-oxide Synthase Protein Thiyl Radical Formation, a Novel Mechanism Regulating eNOS Function and Coupling

An increase in production of reactive oxygen species resulting in a decrease in nitric oxide bioavailability in the endothelium contributes to many cardiovascular diseases, and these reactive oxygen species can oxidize cellular macromolecules. Protein thiols are critical reducing equivalents that ma...

Full description

Saved in:
Bibliographic Details
Main Authors: Chen, Chun-An, Lin, Cho-Hao, Druhan, Lawrence J., Wang, Tse-Yao, Chen, Yeong-Renn, Zweier, Jay L.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190717/
https://ncbi.nlm.nih.gov/pubmed/21666221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.240127
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items