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Reactive Oxygen and Nitrogen Species Regulate Inducible Nitric Oxide Synthase Function Shifting the Balance of Nitric Oxide and Superoxide Production

Inducible NOS (iNOS) is induced in diseases associated with inflammation and oxidative stress, and questions remain regarding its regulation. We demonstrate that reactive oxygen / nitrogen species (ROS/RNS) dose-dependently regulate iNOS function. Tetrahydrobiopterin (BH(4))-replete iNOS was exposed...

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Hlavní autoři: Sun, Jian, Druhan, Lawrence J., Zweier, Jay L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073618/
https://ncbi.nlm.nih.gov/pubmed/19932078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2009.11.019
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