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Reactive Oxygen and Nitrogen Species Regulate Inducible Nitric Oxide Synthase Function Shifting the Balance of Nitric Oxide and Superoxide Production

Inducible NOS (iNOS) is induced in diseases associated with inflammation and oxidative stress, and questions remain regarding its regulation. We demonstrate that reactive oxygen / nitrogen species (ROS/RNS) dose-dependently regulate iNOS function. Tetrahydrobiopterin (BH(4))-replete iNOS was exposed...

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Main Authors: Sun, Jian, Druhan, Lawrence J., Zweier, Jay L.
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073618/
https://ncbi.nlm.nih.gov/pubmed/19932078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2009.11.019
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