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Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages

Superoxide (O(2⨪)) and nitric oxide (NO) act to kill invading microbes in phagocytes. In macrophages NO is synthesized by inducible nitric oxide synthase (iNOS, NOS 2) from l-arginine (l-Arg) and oxygen; however, O(2⨪) was thought to be produced mainly by NADPH oxidase. Electron paramagnetic resonan...

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Autors principals: Xia, Yong, Zweier, Jay L.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences of the USA 1997
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC21266/
https://ncbi.nlm.nih.gov/pubmed/9192673
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