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Phosphorylation of Endothelial Nitric-oxide Synthase Regulates Superoxide Generation from the Enzyme
In the vasculature, nitric oxide (NO) is generated by endothelial NO synthase (eNOS) in a calcium/calmodulin-dependent reaction. With oxidative stress, the critical cofactor BH(4) is depleted, and NADPH oxidation is uncoupled from NO generation, leading to production of ([Formula: see text]). Althou...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2556006/ https://ncbi.nlm.nih.gov/pubmed/18622039 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802269200 |
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