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Phosphorylation of Endothelial Nitric-oxide Synthase Regulates Superoxide Generation from the Enzyme

In the vasculature, nitric oxide (NO) is generated by endothelial NO synthase (eNOS) in a calcium/calmodulin-dependent reaction. With oxidative stress, the critical cofactor BH(4) is depleted, and NADPH oxidation is uncoupled from NO generation, leading to production of ([Formula: see text]). Althou...

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Bibliografiske detaljer
Main Authors: Chen, Chun-An, Druhan, Lawrence J., Varadharaj, Saradhadevi, Chen, Yeong-Renn, Zweier, Jay L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556006/
https://ncbi.nlm.nih.gov/pubmed/18622039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802269200
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