Superoxide Induces Endothelial Nitric-oxide Synthase Protein Thiyl Radical Formation, a Novel Mechanism Regulating eNOS Function and Coupling

An increase in production of reactive oxygen species resulting in a decrease in nitric oxide bioavailability in the endothelium contributes to many cardiovascular diseases, and these reactive oxygen species can oxidize cellular macromolecules. Protein thiols are critical reducing equivalents that ma...

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Main Authors: Chen, Chun-An, Lin, Cho-Hao, Druhan, Lawrence J., Wang, Tse-Yao, Chen, Yeong-Renn, Zweier, Jay L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Enzymology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190717/
https://ncbi.nlm.nih.gov/pubmed/21666221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.240127
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