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Suppression of eNOS-derived superoxide by caveolin-1: a biopterin-dependent mechanism
In the vasculature, nitric oxide (NO) is generated by endothelial NO synthase (eNOS) in a calcium/calmodulin-dependent reaction. In the absence of the requisite eNOS cofactor tetrahydrobiopterin (BH(4)), NADPH oxidation is uncoupled from NO generation, leading to the production of superoxide. Althou...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Physiological Society
2011
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3191102/ https://ncbi.nlm.nih.gov/pubmed/21724868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00936.2010 |
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