Biopterin Metabolism and eNOS Expression during Hypoxic Pulmonary Hypertension in Mice

Tetrahydrobiopterin (BH(4)), which fosters the formation of and stabilizes endothelial NO synthase (eNOS) as an active dimer, tightly regulates eNOS coupling / uncoupling. Moreover, studies conducted in genetically-modified models demonstrate that BH(4) pulmonary deficiency is a key determinant in t...

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Detalhes bibliográficos
Main Authors: Dubois, Mathilde, Delannoy, Estelle, Duluc, Lucie, Closs, Ellen, Li, Huige, Toussaint, Christian, Gadeau, Alain-Pierre, Gödecke, Axel, Freund-Michel, Véronique, Courtois, Arnaud, Marthan, Roger, Savineau, Jean-Pierre, Muller, Bernard
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3842263/
https://ncbi.nlm.nih.gov/pubmed/24312428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082594
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