Biopterin Metabolism and eNOS Expression during Hypoxic Pulmonary Hypertension in Mice

Tetrahydrobiopterin (BH(4)), which fosters the formation of and stabilizes endothelial NO synthase (eNOS) as an active dimer, tightly regulates eNOS coupling / uncoupling. Moreover, studies conducted in genetically-modified models demonstrate that BH(4) pulmonary deficiency is a key determinant in t...

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Autori principali: Dubois, Mathilde, Delannoy, Estelle, Duluc, Lucie, Closs, Ellen, Li, Huige, Toussaint, Christian, Gadeau, Alain-Pierre, Gödecke, Axel, Freund-Michel, Véronique, Courtois, Arnaud, Marthan, Roger, Savineau, Jean-Pierre, Muller, Bernard
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3842263/
https://ncbi.nlm.nih.gov/pubmed/24312428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082594
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