Biphasic roles for soluble guanylyl cyclase (sGC) in platelet activation

Nitric oxide (NO) stimulates cGMP synthesis by activating its intracellular receptor, soluble guanylyl cyclase (sGC). It is a currently prevailing concept that No and cGMP inhibits platelet function. However, the data supporting the inhibitory role of NO/sGC/cGMP in platelets have been obtained eith...

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Detalhes bibliográficos
Main Authors: Zhang, Guoying, Xiang, Binggang, Dong, Anping, Skoda, Radek C., Daugherty, Alan, Smyth, Susan S., Du, Xiaoping, Li, Zhenyu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Platelets and Thrombopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186338/
https://ncbi.nlm.nih.gov/pubmed/21803853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-03-341107
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