Dynamic Ligand Exchange in Soluble Guanylyl Cyclase (sGC): IMPLICATIONS FOR sGC REGULATION AND DESENSITIZATION

Accumulating evidence indicates that the functional properties of soluble guanylyl cyclase (sGC) are affected not only by the binding of NO but also by the NO:sGC ratio and a number of cellular factors, including GTP. In this study, we monitored the time-resolved transformations of sGC and sGC-NO co...

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Bibliographic Details
Main Authors: Tsai, Ah-Lim, Berka, Vladimir, Sharina, Iraida, Martin, Emil
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234846/
https://ncbi.nlm.nih.gov/pubmed/22009742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.290304
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