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Characterization of oxidized guanosine 5’-triphosphate (oxo(8)GTP) as a viable inhibitor of soluble guanylyl cyclase (sGC)
The guanine base is liable for oxidation by free radicals regardless of the cellular moiety it is bound to. However, under conditions of oxidative stress, oxo(8)GTP formation has been shown to occur without oxidation to the guanine base in DNA. In vitro studies have suggested that oxo(8)GTP could im...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2814594/ https://ncbi.nlm.nih.gov/pubmed/19167482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2008.12.021 |
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