Synergistic mutations in soluble guanylyl cyclase (sGC) reveal a key role for interfacial regions in the sGC activation mechanism

Soluble guanylyl cyclase (sGC) is the main receptor for nitric oxide (NO) and a central component of the NO-cGMP pathway, critical to cardiovascular function. NO binding to the N-terminal sensor domain in sGC enhances the cyclase activity of the C-terminal catalytic domain. Our understanding of the...

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Gepubliceerd in:J Biol Chem
Hoofdauteurs: Childers, Kenneth C., Yao, Xin-Qiu, Giannakoulias, Sam, Amason, Joshua, Hamelberg, Donald, Garcin, Elsa D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6885636/
https://ncbi.nlm.nih.gov/pubmed/31645439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011010
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