A Monoclonal Antibody Against Synthetic Aβ Dimer Assemblies Neutralizes Brain-Derived Synaptic Plasticity-Disrupting Aβ

Diverse lines of evidence indicate that pre-fibrillar, diffusible assemblies of the amyloid β-protein play an important role in Alzheimer’s disease pathogenesis. Although the precise molecular identity of these soluble toxins remains unsettled, recent experiments suggest that SDS-stable amyloid β-pr...

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Detalhes bibliográficos
Main Authors: O'Nuallain, Brian, Klyubin, Igor, Mc Donald, Jessica M., Foster, James S., Welzel, Alfred, Barry, Andrew, Dykoski, Richard K., Cleary, James P., Gebbink, Martijn F.B.G., Rowan, Michael J., Walsh, Dominic M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174526/
https://ncbi.nlm.nih.gov/pubmed/21781116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2011.07389.x
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