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Amyloid β-Protein Dimers Rapidly Form Stable Synaptotoxic Protofibrils
Nonfibrillar, water-soluble low-molecular weight assemblies of the amyloid β-protein (Aβ) are believed to play an important role in Alzheimer's disease (AD). Aqueous extracts of human brain contain Aβ assemblies that migrate on SDS-polyacrylamide gels and elute from size exclusion as dimers (∼8...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Society for Neuroscience
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2987723/ https://ncbi.nlm.nih.gov/pubmed/20980598 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3537-10.2010 |
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