Amyloid β-Protein Dimers Rapidly Form Stable Synaptotoxic Protofibrils

Nonfibrillar, water-soluble low-molecular weight assemblies of the amyloid β-protein (Aβ) are believed to play an important role in Alzheimer's disease (AD). Aqueous extracts of human brain contain Aβ assemblies that migrate on SDS-polyacrylamide gels and elute from size exclusion as dimers (∼8...

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Main Authors: O'Nuallain, Brian, Freir, Darragh B., Nicoll, Andrew J., Risse, Emmanuel, Ferguson, Neil, Herron, Caroline E., Collinge, John, Walsh, Dominic M.
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2010
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2987723/
https://ncbi.nlm.nih.gov/pubmed/20980598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3537-10.2010
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