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Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites

A role for PrP in the toxic effect of oligomeric forms of Aβ, implicated in Alzheimer's disease (AD), has been suggested but remains controversial. Here we show that PrP is required for the plasticity-impairing effects of ex vivo material from human AD brain and that standardized Aβ-derived dif...

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Hlavní autoři: Freir, Darragh B., Nicoll, Andrew J., Klyubin, Igor, Panico, Silvia, Mc Donald, Jessica M., Risse, Emmanuel, Asante, Emmanuel A., Farrow, Mark A., Sessions, Richard B., Saibil, Helen R., Clarke, Anthony R., Rowan, Michael J., Walsh, Dominic M., Collinge, John
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3156817/
https://ncbi.nlm.nih.gov/pubmed/21654636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1341
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