Identification of a Compound That Disrupts Binding of Amyloid-β to the Prion Protein Using a Novel Fluorescence-based Assay

The prion protein (PrP) has been implicated both in prion diseases such as Creutzfeldt-Jakob disease, where its monomeric cellular isoform (PrP(C)) is recruited into pathogenic self-propagating polymers of misfolded protein, and in Alzheimer disease, where PrP(C) may act as a receptor for synaptotox...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Risse, Emmanuel, Nicoll, Andrew J., Taylor, William A., Wright, Daniel, Badoni, Mayank, Yang, Xiaofan, Farrow, Mark A., Collinge, John
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505445/
https://ncbi.nlm.nih.gov/pubmed/25995455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.637124
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