Mechanisms of prion protein assembly into amyloid

The conversion of the α-helical, cellular isoform of the prion protein (PrP(C)) to the insoluble, β-sheet-rich, infectious, disease-causing isoform (PrP(Sc)) is the key event in prion diseases. In an earlier study, several forms of PrP were converted into a fibrillar state by using an in vitro conve...

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Detalhes bibliográficos
Main Authors: Stöhr, Jan, Weinmann, Nicole, Wille, Holger, Kaimann, Tina, Nagel-Steger, Luitgard, Birkmann, Eva, Panza, Giannantonio, Prusiner, Stanley B., Eigen, Manfred, Riesner, Detlev
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268150/
https://ncbi.nlm.nih.gov/pubmed/18268326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712036105
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