Human Anti-Aβ IgGs Target Conformational Epitopes on Synthetic Dimer Assemblies and the AD Brain-Derived Peptide

Soluble non-fibrillar assemblies of amyloid-beta (Aβ) and aggregated tau protein are the proximate synaptotoxic species associated with Alzheimer’s disease (AD). Anti-Aβ immunotherapy is a promising and advanced therapeutic strategy, but the precise Aβ species to target is not yet known. Previously,...

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Autori principali: Welzel, Alfred T., Williams, Angela D., McWilliams-Koeppen, Helen P., Acero, Luis, Weber, Alfred, Blinder, Veronika, Mably, Alex, Bunk, Sebastian, Hermann, Corinna, Farrell, Michael A., Ehrlich, Hartmut J., Schwarz, Hans P., Walsh, Dominic M., Solomon, Alan, O’Nuallain, Brian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507685/
https://ncbi.nlm.nih.gov/pubmed/23209707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050317
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