Human Anti-Aβ IgGs Target Conformational Epitopes on Synthetic Dimer Assemblies and the AD Brain-Derived Peptide

Soluble non-fibrillar assemblies of amyloid-beta (Aβ) and aggregated tau protein are the proximate synaptotoxic species associated with Alzheimer’s disease (AD). Anti-Aβ immunotherapy is a promising and advanced therapeutic strategy, but the precise Aβ species to target is not yet known. Previously,...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Welzel, Alfred T., Williams, Angela D., McWilliams-Koeppen, Helen P., Acero, Luis, Weber, Alfred, Blinder, Veronika, Mably, Alex, Bunk, Sebastian, Hermann, Corinna, Farrell, Michael A., Ehrlich, Hartmut J., Schwarz, Hans P., Walsh, Dominic M., Solomon, Alan, O’Nuallain, Brian
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2012
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507685/
https://ncbi.nlm.nih.gov/pubmed/23209707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050317
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