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Tapping natural reservoirs of homing endonucleases for targeted gene modification

Homing endonucleases mobilize their own genes by generating double-strand breaks at individual target sites within potential host DNA. Because of their high specificity, these proteins are used for “genome editing” in higher eukaryotes. However, alteration of homing endonuclease specificity is quite...

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Bibliografski detalji
Glavni autori: Takeuchi, Ryo, Lambert, Abigail R., Mak, Amanda Nga-Sze, Jacoby, Kyle, Dickson, Russell J., Gloor, Gregory B., Scharenberg, Andrew M., Edgell, David R., Stoddard, Barry L.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3156218/
https://ncbi.nlm.nih.gov/pubmed/21784983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1107719108
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