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Homing endonucleases: from microbial genetic invaders to reagents for targeted DNA modification

Homing endonucleases are microbial DNA-cleaving enzymes that mobilize their own reading frames by generating double strand breaks at specific genomic invasion sites. These proteins display an economy of size, and yet recognize long DNA sequences (typically 20 to 30 basepairs). They exhibit a wide ra...

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Bibliografische gegevens
Hoofdauteur: Stoddard, Barry L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038549/
https://ncbi.nlm.nih.gov/pubmed/21220111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2010.12.003
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