Comparison of the Safety and Pharmacokinetics of ST-246® after IV Infusion or Oral Administration in Mice, Rabbits and Monkeys

BACKGROUND: ST-246® is an antiviral, orally bioavailable small molecule in clinical development for treatment of orthopoxvirus infections. An intravenous (IV) formulation may be required for some hospitalized patients who are unable to take oral medication. An IV formulation has been evaluated in th...

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Detalhes bibliográficos
Main Authors: Chen, Yali, Amantana, Adams, Tyavanagimatt, Shanthakumar R., Zima, Daniela, Yan, X. Steven, Kasi, Gopi, Weeks, Morgan, Stone, Melialani A., Weimers, William C., Samuel, Peter, Tan, Ying, Jones, Kevin F., Lee, Daniel R., Kickner, Shirley S., Saville, Bradley M., Lauzon, Martin, McIntyre, Alan, Honeychurch, Kady M., Jordan, Robert, Hruby, Dennis E., Leeds, Janet M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3156126/
https://ncbi.nlm.nih.gov/pubmed/21858040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023237
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