Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH)

The synthesis and structure–activity relationships (SAR) of a series of benzothiophene piperazine and piperidine urea FAAH inhibitors is described. These compounds inhibit FAAH by covalently modifying the enzyme’s active site serine nucleophile. Activity-based protein profiling (ABPP) revealed that...

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Bibliografiska uppgifter
Huvudupphovsmän: Johnson, Douglas S., Ahn, Kay, Kesten, Suzanne, Lazerwith, Scott E., Song, Yuntao, Morris, Mark, Fay, Lorraine, Gregory, Tracy, Stiff, Cory, Dunbar, James B., Liimatta, Marya, Beidler, David, Smith, Sarah, Nomanbhoy, Tyzoon K., Cravatt, Benjamin F.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150822/
https://ncbi.nlm.nih.gov/pubmed/19386497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.03.080
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