Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH)

The synthesis and structure–activity relationships (SAR) of a series of benzothiophene piperazine and piperidine urea FAAH inhibitors is described. These compounds inhibit FAAH by covalently modifying the enzyme’s active site serine nucleophile. Activity-based protein profiling (ABPP) revealed that...

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主要な著者: Johnson, Douglas S., Ahn, Kay, Kesten, Suzanne, Lazerwith, Scott E., Song, Yuntao, Morris, Mark, Fay, Lorraine, Gregory, Tracy, Stiff, Cory, Dunbar, James B., Liimatta, Marya, Beidler, David, Smith, Sarah, Nomanbhoy, Tyzoon K., Cravatt, Benjamin F.
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150822/
https://ncbi.nlm.nih.gov/pubmed/19386497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.03.080
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