Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor

[Image: see text] Fatty acid amide hydrolase (FAAH) is an integral membrane serine hydrolase that degrades the fatty acid amide family of signaling lipids, including the endocannabinoid anandamide. Genetic or pharmacological inactivation of FAAH leads to analgesic and anti-inflammatory phenotypes in...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Johnson, Douglas S., Stiff, Cory, Lazerwith, Scott E., Kesten, Suzanne R., Fay, Lorraine K., Morris, Mark, Beidler, David, Liimatta, Marya B., Smith, Sarah E., Dudley, David T., Sadagopan, Nalini, Bhattachar, Shobha N., Kesten, Stephen J., Nomanbhoy, Tyzoon K., Cravatt, Benjamin F., Ahn, Kay
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Chemical Society 2010
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109749/
https://ncbi.nlm.nih.gov/pubmed/21666860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100190t
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