Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor

[Image: see text] Fatty acid amide hydrolase (FAAH) is an integral membrane serine hydrolase that degrades the fatty acid amide family of signaling lipids, including the endocannabinoid anandamide. Genetic or pharmacological inactivation of FAAH leads to analgesic and anti-inflammatory phenotypes in...

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Detalhes bibliográficos
Main Authors: Johnson, Douglas S., Stiff, Cory, Lazerwith, Scott E., Kesten, Suzanne R., Fay, Lorraine K., Morris, Mark, Beidler, David, Liimatta, Marya B., Smith, Sarah E., Dudley, David T., Sadagopan, Nalini, Bhattachar, Shobha N., Kesten, Stephen J., Nomanbhoy, Tyzoon K., Cravatt, Benjamin F., Ahn, Kay
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2010
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109749/
https://ncbi.nlm.nih.gov/pubmed/21666860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100190t
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