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Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor

[Image: see text] Fatty acid amide hydrolase (FAAH) is an integral membrane serine hydrolase that degrades the fatty acid amide family of signaling lipids, including the endocannabinoid anandamide. Genetic or pharmacological inactivation of FAAH leads to analgesic and anti-inflammatory phenotypes in...

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書誌詳細
主要な著者: Johnson, Douglas S., Stiff, Cory, Lazerwith, Scott E., Kesten, Suzanne R., Fay, Lorraine K., Morris, Mark, Beidler, David, Liimatta, Marya B., Smith, Sarah E., Dudley, David T., Sadagopan, Nalini, Bhattachar, Shobha N., Kesten, Stephen J., Nomanbhoy, Tyzoon K., Cravatt, Benjamin F., Ahn, Kay
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2010
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109749/
https://ncbi.nlm.nih.gov/pubmed/21666860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100190t
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