Structure-guided inhibitor design for human FAAH by interspecies active site conversion

The integral membrane enzyme fatty acid amide hydrolase (FAAH) hydrolyzes the endocannabinoid anandamide and related amidated signaling lipids. Genetic or pharmacological inactivation of FAAH produces analgesic, anxiolytic, and antiinflammatory phenotypes but not the undesirable side effects of dire...

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Detalles Bibliográficos
Autores principales: Mileni, Mauro, Johnson, Douglas S., Wang, Zhigang, Everdeen, Daniel S., Liimatta, Marya, Pabst, Brandon, Bhattacharya, Keshab, Nugent, Richard A., Kamtekar, Satwik, Cravatt, Benjamin F., Ahn, Kay, Stevens, Raymond C.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2008
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529035/
https://ncbi.nlm.nih.gov/pubmed/18753625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806121105
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