Structure-guided inhibitor design for human FAAH by interspecies active site conversion

The integral membrane enzyme fatty acid amide hydrolase (FAAH) hydrolyzes the endocannabinoid anandamide and related amidated signaling lipids. Genetic or pharmacological inactivation of FAAH produces analgesic, anxiolytic, and antiinflammatory phenotypes but not the undesirable side effects of dire...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Mileni, Mauro, Johnson, Douglas S., Wang, Zhigang, Everdeen, Daniel S., Liimatta, Marya, Pabst, Brandon, Bhattacharya, Keshab, Nugent, Richard A., Kamtekar, Satwik, Cravatt, Benjamin F., Ahn, Kay, Stevens, Raymond C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529035/
https://ncbi.nlm.nih.gov/pubmed/18753625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806121105
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados