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Crystal Structures of Fatty Acid Amide Hydrolase Bound to the Carbamate Inhibitor URB597: Discovery of a Deacylating Water Molecule and Insight into Enzyme Inactivation

The endocannabinoid system regulates a wide range of physiological processes including pain, inflammation, and cognitive/emotional states. URB597 is one of the best characterized covalent inhibitors of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH). Here, we report the struct...

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Detalhes bibliográficos
Main Authors: Mileni, Mauro, Kamtekar, Satwik, Wood, David C., Benson, Timothy E., Cravatt, Benjamin F., Stevens, Raymond C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014312/
https://ncbi.nlm.nih.gov/pubmed/20493882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.05.034
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