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The fatty-acid amide hydrolase inhibitor URB597 inhibits MICA/B shedding
MICA/B proteins are expressed on the surface of various types of stressed cells, including cancer cells. Cytotoxic lymphocytes expressing natural killer group 2D (NKG2D) receptor recognize MICA/B and eliminate the cells. However, cancer cells evade such immune recognition by inducing proteolytic she...
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| Опубликовано в: : | Sci Rep |
|---|---|
| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7512021/ https://ncbi.nlm.nih.gov/pubmed/32968163 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72688-y |
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