Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain

The endogenous cannabinoid (endocannabinoid) anandamide is principally degraded by the integral membrane enzyme fatty acid amide hydrolase (FAAH). Pharmacological blockade of FAAH has emerged as a potentially attractive strategy for augmenting endocannabinoid signaling and retaining the beneficial e...

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Detaylı Bibliyografya
Asıl Yazarlar: Ahn, Kay, Smith, Sarah E., Liimatta, Marya B., Beidler, David, Sadagopan, Nalini, Dudley, David T., Young, Tim, Wren, Paul, Zhang, Yanhua, Swaney, Steven, Van Becelaere, Keri, Blankman, Jacqueline L., Nomura, Daniel K., Bhattachar, Shobha N., Stiff, Cory, Nomanbhoy, Tyzoon K., Weerapana, Eranthie, Johnson, Douglas S., Cravatt, Benjamin F.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2011
Konular:
Drug Discovery and Translational Medicine
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126636/
https://ncbi.nlm.nih.gov/pubmed/21505060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.180257
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