Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain

The endogenous cannabinoid (endocannabinoid) anandamide is principally degraded by the integral membrane enzyme fatty acid amide hydrolase (FAAH). Pharmacological blockade of FAAH has emerged as a potentially attractive strategy for augmenting endocannabinoid signaling and retaining the beneficial e...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Ahn, Kay, Smith, Sarah E., Liimatta, Marya B., Beidler, David, Sadagopan, Nalini, Dudley, David T., Young, Tim, Wren, Paul, Zhang, Yanhua, Swaney, Steven, Van Becelaere, Keri, Blankman, Jacqueline L., Nomura, Daniel K., Bhattachar, Shobha N., Stiff, Cory, Nomanbhoy, Tyzoon K., Weerapana, Eranthie, Johnson, Douglas S., Cravatt, Benjamin F.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
Assuntos:
Drug Discovery and Translational Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126636/
https://ncbi.nlm.nih.gov/pubmed/21505060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.180257
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados