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Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor
[Image: see text] Fatty acid amide hydrolase (FAAH) is an integral membrane serine hydrolase that degrades the fatty acid amide family of signaling lipids, including the endocannabinoid anandamide. Genetic or pharmacological inactivation of FAAH leads to analgesic and anti-inflammatory phenotypes in...
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| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Chemical Society
2010
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3109749/ https://ncbi.nlm.nih.gov/pubmed/21666860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100190t |
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