Metalloprotease Meprin β Generates Nontoxic N-terminal Amyloid Precursor Protein Fragments in Vivo

Identification of physiologically relevant substrates is still the most challenging part in protease research for understanding the biological activity of these enzymes. The zinc-dependent metalloprotease meprin β is known to be expressed in many tissues with functions in health and disease. Here, w...

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Detalhes bibliográficos
Main Authors: Jefferson, Tamara, Čaušević, Mirsada, auf dem Keller, Ulrich, Schilling, Oliver, Isbert, Simone, Geyer, Rebecca, Maier, Wladislaw, Tschickardt, Sabrina, Jumpertz, Thorsten, Weggen, Sascha, Bond, Judith S., Overall, Christopher M., Pietrzik, Claus U., Becker-Pauly, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149364/
https://ncbi.nlm.nih.gov/pubmed/21646356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.252718
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