Metalloprotease Meprin β Generates Nontoxic N-terminal Amyloid Precursor Protein Fragments in Vivo

Identification of physiologically relevant substrates is still the most challenging part in protease research for understanding the biological activity of these enzymes. The zinc-dependent metalloprotease meprin β is known to be expressed in many tissues with functions in health and disease. Here, w...

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Bibliographic Details
Main Authors: Jefferson, Tamara, Čaušević, Mirsada, auf dem Keller, Ulrich, Schilling, Oliver, Isbert, Simone, Geyer, Rebecca, Maier, Wladislaw, Tschickardt, Sabrina, Jumpertz, Thorsten, Weggen, Sascha, Bond, Judith S., Overall, Christopher M., Pietrzik, Claus U., Becker-Pauly, Christoph
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Protein Synthesis and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149364/
https://ncbi.nlm.nih.gov/pubmed/21646356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.252718
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