Probing the interactions of an acyl carrier protein domain from the 6-deoxyerythronolide B synthase

The assembly-line architecture of polyketide synthases (PKSs) provides an opportunity to rationally reprogram polyketide biosynthetic pathways to produce novel antibiotics. A fundamental challenge toward this goal is to identify the factors that control the unidirectional channeling of reactive bios...

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Main Authors: Charkoudian, Louise K, Liu, Corey W, Capone, Stefania, Kapur, Shiven, Cane, David E, Togni, Antonio, Seebach, Dieter, Khosla, Chaitan
Format: Artigo
Sprog:Inglês
Udgivet: Wiley Subscription Services, Inc., A Wiley Company 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149197/
https://ncbi.nlm.nih.gov/pubmed/21563224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.652
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