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Stereospecificity of Ketoreductase Domains of the 6-Deoxyerythronolide B Synthase
6-Deoxyerythronolide B synthase (DEBS) is a modular polyketide synthase (PKS) responsible for the biosynthesis of 6-dEB (1), the parent aglycone of the broad spectrum macrolide antibiotic erythromycin. Individual DEBS modules, which contain the catalytic domains necessary for each step of polyketide...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2547127/ https://ncbi.nlm.nih.gov/pubmed/17918944 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja0753290 |
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