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Structural and Mechanistic Analysis of Protein Interactions in Module 3 of the 6-Deoxyerythronolide B Synthase
We report the 2.6-Å X-ray crystal structure of a 190-kDa homodimeric fragment from module 3 of the 6-deoxyerthronolide B synthase covalently bound to the inhibitor cerulenin. The structure shows two well-organized interdomain linker regions in addition to the full-length ketosynthase (KS) and acyltr...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1986752/ https://ncbi.nlm.nih.gov/pubmed/17719492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2007.07.012 |
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