Structural and Mechanistic Analysis of Protein Interactions in Module 3 of the 6-Deoxyerythronolide B Synthase

We report the 2.6-Å X-ray crystal structure of a 190-kDa homodimeric fragment from module 3 of the 6-deoxyerthronolide B synthase covalently bound to the inhibitor cerulenin. The structure shows two well-organized interdomain linker regions in addition to the full-length ketosynthase (KS) and acyltr...

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Bibliographic Details
Main Authors: Tang, Yinyan, Chen, Alice Y., Kim, Chu-Young, Cane, David E., Khosla, Chaitan
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1986752/
https://ncbi.nlm.nih.gov/pubmed/17719492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2007.07.012
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