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Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects

Glucocorticoids (GCs) are the most commonly used antiinflammatory and immunosuppressive drugs. Their outstanding therapeutic effects, however, are often accompanied by severe and sometimes irreversible side effects. For this reason, one goal of research in the GC field is the development of new drug...

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Furkejuvvon:
Publikašuvnnas:Proc Natl Acad Sci U S A
Váldodahkkit: Schäcke, Heike, Schottelius, Arndt, Döcke, Wolf-Dietrich, Strehlke, Peter, Jaroch, Stefan, Schmees, Norbert, Rehwinkel, Hartmut, Hennekes, Hartwig, Asadullah, Khusru
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: National Academy of Sciences 2003
Fáttát:
Biological Sciences
Liŋkkat:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC314167/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14694204/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0300372101
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