Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects

Glucocorticoids (GCs) are the most commonly used antiinflammatory and immunosuppressive drugs. Their outstanding therapeutic effects, however, are often accompanied by severe and sometimes irreversible side effects. For this reason, one goal of research in the GC field is the development of new drug...

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Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Schäcke, Heike, Schottelius, Arndt, Döcke, Wolf-Dietrich, Strehlke, Peter, Jaroch, Stefan, Schmees, Norbert, Rehwinkel, Hartmut, Hennekes, Hartwig, Asadullah, Khusru
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 2003
Materias:	Biological Sciences
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC314167/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14694204/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0300372101
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